Synthesis, Characterization and Biochemical impacts of some new bioactive sulfonamide thiazole derivatives as potential insecticidal agents against the cotton leafworm, Spodoptera littoralis.

A novel series of anticipated biologically active heterocyclic compounds such as pyrazole, thiazole, pyridine, acrylamide, thiophene, triazolo[1,5-a]pyrimidine, imidazolidine, aminopyrazole, pyrazolo[5,1-c][1,2,4]triazine, triazolo[4,3-a]pyrimidine, benzo[4,5]imidazo[1,2-a]pyrimidine, pyrido[2',3':3,4]pyrazolo[5,1-c][1,2,4]triazine, isoxazole, benzo[4,5]imidazo[2,1-c][1,2,4]triazine, pyrimidine, pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidine, pyrano[2,3-d]pyrimidine and chromene derivatives incorporating Sulfonamide-bearing thiazole moiety suitable for utilize as insecticidal agents were synthesized via a versatile, readily accessible cyanoacetanilide, 2-cyano-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide (1).The structures of the newly synthesized compounds were elucidated by IR, MS, 1H NMR, 13C NMR, DEPT, H-H COSY, HMBC, and HSQC spectral analysis. Toxicological, biochemical parameters and biological aspects of the demonstrative compounds of the synthesized products against the cotton leafworm, Spodoptera littoralis under laboratory conditions were also investigated. Regarding the determined LC50 and LC90 values, sulfonamides bearing thiazole moiety 16a, 8, 28 and 31b showed the most potent toxic effects with LC50 values of 49.04, 62.66, 78.62, 94.90 and 105.10 ppm, respectively, and toxicity index being 100, 78.26, 62.38, 51.68 and 46.66%, respectively.