Study on the correlation of cytokines and the angiogenesis of diabetic foot

In recent years, cytokine-based therapy for diabetic foot has attracted much attention, and the dynamic balance between angiogenesis-promoting factors and inhibitors was the key to maintain the normal occurrence of wound healing. Mechanism of cytokines of angiogenesis-promoting (vascular endothelial growth factor, hypoxia-inducible factor-1, fibroblast growth factor, platelet-derived growth factor, et al.) and inhibitors (pigment epithelium derived factor and kallikrein binding protein ) were expounded. The aim was to provide a new protocol for the treatment of diabetic foot with cytokines. Key words: Diabetic foot; Cytokine; Angiogenesis