Genetic Variants Account for Differences in Responses in Blood Pressure and Blood Flow Values to Laryngoscopy/Intubation/Extubation

Results: During laryngoscopy, intubation and extubation, blood pressure, heart rate and rate pressure product (RPP) values increased, returning to baseline within five minutes. Increases at Ti were significant for all values when compared to T0 (p<0.01, p<0.001). At Ti, genotype associations were observed between DRD1 -48GG genotype and systolic and diastolic blood pressures and also between heart rate and ADRB2 Arg/Arg and ACE II. Patients having ACE ID and ADRB2 Arg/Arg and ACE II and DRD1 GG genotypes were associated with a significant increase in diastolic blood pressure and heart rate at Ti, respectively (p<0.01, p<0.001). Conclusions: These results indicate that single nucleotide polymorphisms in DRD1, ADRB3 and ACE genes may have an impact on hemodynamic changes during laryngoscopy/intubation/extubation.