Methodological considerations in the evaluation of radiotherapy technologies

*University of Cambridge, Department of Oncology, Addenbrooke’s Hospital, Cambridge, UK yMRC Midland Hub for Trials Methodology Research and Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK zNational Cancer Research Institute, London, UK xClinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK {Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK jjGray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK ** The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK yy Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK zz School of Cancer and Imaging Science, University of Manchester, Manchester, UK