Improved Neuroprotection with Melatonin-Augmented Hypothermia vs Hypothermia Alone in a Perinatal Asphyxia Model: a Randomized Study

Background: Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring hormone, anti-oxidant and cellular pro-survival factor, used safely in children with sleep disorders. Melatonin is beneficial following brain injury in adult animals. It is unknown if melatonin augments hypothermic neuroprotection in the developing brain.