Oxadiazole and thiadiazole derivatives of pyrrolidine oxime are oxytocin receptor antagonists

Oxadiazole derivatives and thiadiazole pyrrolidine in accordance with formula I: as well as its geometrical isomers, its optically active forms as enantiomers, Ysus diastereomeric racemates, and pharmaceutically acceptable salts thereof, where: A is selected from the group consisting of - (C> = O) -, - (C> = O) -O-, -SO2-, -SO2NH-, -CH2-. B is a oxadiazole or thiadiazole ring. R1 is selected from the group comprising or consisting of H or C1-C3 R2 is selected from the group comprising or consisting of aryl groups or aryl-C1-C6 alkyl, R3, R4, R5 and R6 are hydrogen, where aryl and refers to an aromatic carboxylic unsaturated group of 6 to 14atomo carbon with a single ring or multiple condemned ring which may be substituted with 1 to 5sustituyente selected from the group consisting of C1-C6 alkyl, C2-C6 term alkynyl C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl C1-C6 alkyl, heteroaryl- C1-C6 alkyl, cycloalkyl-C1-C6 alkyl, heterocycloalkyl-C1-C6, amino, ammonium, acyl, acyloxy, acylamino, aminocarbonyl, acoxicarbonilo, ureido, carbamate, aryl, heteroaryl, sulfinyl, sulfonyl, alkoxy, sulfanyl, halogen, carboxy, trialometilo, cyano, hydroxy, mercapto and nitro.