Reduced plasma cyclic GMP but normal renal responses to atrial natriuretic factor in pre-hypertension

Ferrari P, Gadient G, Cozzio A, Shaw S, Weidmann P. Reduced plasma cyclic GMP hut normal rend responses to atrial natriuretic, factor in pre-hypertension.The amount of, and response of the kidneys to, endogenous natriuretic factor(s) could be important in the pathogenesis of essential hypertension. Searching for possible disturbance(s) related to atrial natriuretic factor (ANF) and its second messenger, cyclic guanosine monophosphate (c-GMP), we assessed plasma immunoreactive (ir) ANF and c-GMP, effective renal plasma flow (ERPF), glomerular filtration rate (GFR), urinary c-GMP, absolute and fractional (FE) excretions of sodium(Na) and chloride (CI) before and during infusions of low ANF doses or vehicle (V) in 7 normotensive sons of essential hypertensive parents (SEH) compared with 7 sons of normotensive parents (SN). Each subject was infused at 2-week intervals in a single-blind randomized sequence with 4 different solutions: V only or ANF 0.004, 0.008 and 0.016μ/kg/min, infused over 90 min. Plasma irA...