Pattern of HIV risk behavior in a cohort of high risk women in East Africa

Background Development of high risk cohorts is critical for advanced HIV vaccine testing. Prevention interventions during follow up of such cohorts could influence the pattern of risk behavior leading to unmet study outcomes. We examined risk behaviors among high risk women enrolled in a prospective cohort to determine changes over time. Methods Adult women self identified as sex workers or bar workers were enrolled in an open cohort at three sites in East Africa. HIV risk factors were assessed at baseline and every six months for 1½ years, using Audio Computer Assisted Self Interview (ACASI). Participants were also evaluated twice weekly to identify HIV infection. HIV counseling was done every 3 months and when required during twice weekly visits. Male condoms were made available at all visits. Data was analyzed using Fisher’s exact test. Results Data is available for 1158 HIV negative participants at baseline and 771(66.6%), 537 (46.4%), 403 (34.8 %) participants at 6, 12 and18 months respectively and 37 acute HIV infections. Overall, the risk status of Tanzania women was lower compared to Kenya and Uganda. There was a significant drop in proportion of participants reporting sex with ≥ 3 Non-spouse/Non-cohabitating male partners and sex with high risk partners at 6 months (25.3%, 39.0%) compared to baseline (55.4 %, 62.0%)( p 6-12 and >12-18 months.