Perspectives on HCV Cure

The development of interferon-free cures for hepatitis C has revolutionized the treatment of patients chronically infected with the hepatitis C virus. Since 2010, ten new curative regimens have been introduced into clinical practice. These new regimens have delivered cure rates in excess of 95% in as little as 8–10 weeks on therapy. Never before has there been an absolute cure for a chronic viral disease. This medical breakthrough has been made possible by the commitment of scientists and clinicians from both academia and industry working toward a common goal. Because of the availability of these curative regimens, it is now possible to contemplate eliminating HCV as a global public health problem as outlined by the World Health Organization. This perspective will give a brief commentary of the achievements and future possibilities provided by direct-acting antiviral interferon-free HCV cure therapies.