Captopril Induced Pemphigus Vulgaris

A 51 Year old man, was taking captopril 200 mg daily' for the management of essential hypertension. Twenty two days after starting captopril, he developed flaccid vescicles and bullae over his scalp, face, trunk and mucous membranes of the mouth. Clinical and histopathological features were consistent with the diagnosis of pemphigus vulgaris' Complete disappearance of the skin lesions within. 15 days of withdrawing the drug and absence of any recurrences in one year follow-up suggest that captopril was the probable offending drug.