Regulation of Th1/Th2 cells in asthma development: A mathematical model
2013
Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type II
helper T cell induced experimental asthma. While high LPS levels induce Th1-dominant
responses, low LPS levels derive Th2 cell induced
asthma. The present paper develops a mathematical model of asthma development which
focuses on the relative balance of Th1 and Th2 cell induced asthma. In the present work
we represent
the complex network of interactions between cells and molecules by a mathematical model.
The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages)
and regulatory molecules (IFN-$\gamma$, IL-4, IL-12, TNF-α) in response to
high, intermediate, and low levels of LPS.
The simulations show how
variations in the levels of injected LPS
affect the development of
Th1 or Th2 cell responses through differential cytokine induction.
The model also predicts the coexistence of
these two types of response
under certain biochemical and biomechanical conditions in the microenvironment.
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