Prevention of rat islet cell allograft rejection by pretreatment with anti-dentritic cell McAb

Streptozotocin-induced diabetic model was established in rats. Seven days later, McAb to dentritic cell (WZDs), fresh separated dentritic cells (DC) and WZDs pretreated with islet cells were injected individually into the rat models to observe the effects of DC on the survival time of grafted islet cells and the roles of WZDs against rejection. The levels of blood sugar and serum insulin in the rats were determined every two days. The results showed that the concentrations of blood sugar was decreased and the level of serum insulin increased in the recipients receiving pretreated-islet and (or) given WZDs. It is indicated that DC is a potentially important component of transplantation and WZDs can prolong survival time of the allografts. Key words: Islands langerhans/transplantation; Rejection; Immunotherapy