Bisoprolol oral treatment of heart failure rats: Involvement of calmodulin

Abstract Objectives The current study is to estimate the bisoprolol (BOP) oral treatment of rats against the myocardial infarction (MI) administrated by using isoproterenol (ISO). Methods: Treatment of rats are MI administration by subcutaneous for two successive days of ISO (85 mg/kg). The tissue of heart is removed without delay, it is washed used isotonic chilled saline in this study. Plasma is separated from the collected rat blood and further analysis of biochemical parameters were carried out. Results: Group of ISO-treated rats have increased levels of glucose in blood, also observed the activity of lipids in plasma along fibres of muscle with hyalinization, compared to BOP treated rats, and ISO + BOP treated rats. The parameter values of BOP administered rat were close to control rats. Reports clearly state that ISO + BOP treated rat tissue of heart damage is reduced when compared to ISO treated rats. Conclusions: Rats were treated with ISO + BOP to defend against hyperlipidaemia and tissue of cardiac damage and followed by MI. Hence, to investigate the biochemical and biophysical BOP mechanism against MI risk in rats.