Improved anti-tumor efficacy via combination of oxaliplatin and fibrin glue in colorectal cancer

// Yuzhu Hu 1 , Ting Yu 1 , Xiaoxiao Liu 1 , Yihong He 1 , Lihong Deng 1 , Jiajuan Guo 1 , Yuanqi Hua 1 , Ting Luo 1 and Xiang Gao 2 1 Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China 2 Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China Correspondence to: Xiang Gao, email: xiangxianggao2008@163.com Ting Luo, email: tina621@163.com Keywords: colorectal cancer; oxaliplatin; fibrin glue; anti-tumor activity; cell proliferation Received: October 17, 2017     Accepted: December 05, 2017     Published: December 20, 2017 ABSTRACT Colorectal cancer is very common worldwide and advanced colorectal cancer exhibited very poor clinical outcome. Oxaliplatin (OXP) is one of the principal chemotherapeutic agents in colorectal cancer treatment presenting impressive anti-tumor ability, limited by adverse effect in clinical practice. Fibrin glue (FG) is a biocompatible formulation made of fibrinogen and thrombin, extensively used in surgery for hemostasis, tissue adhesion and sealing. In this study, FG was innovatively applied as OXP delivery system and results showed enhanced anti-tumor performance in subcutaneous model and abdominal metastasis model of murine colorectal cancer compared with that of OXP used alone. It is revealed that combination of OXP and FG could increase activated CD8 + T cells, reduce regulatory T (Treg) cells and increase interferon-γ (IFN-γ). Furthermore, results showed promoted tumor apoptosis, decreased proliferation and inhibited tumor angiogenesis by OXP and FG combination. No obvious systemic toxicity was observed in this study. Finally, our findings provided basis for promising application of OXP and FG combination in colorectal cancer treatment.