Autologous Transplantation of Bone-marrow Mononuclear Cells for Treating Patients with Neurological Impairment (A Report of 5 Cases)

Objective:To investigate the efficacy and security of autologous transplantation of bone-marrow mononuclear cells for the treatment of patients with neurological impairment.Methods: Five patients with neurological impairment were treated by autologous transplantation of bone-marrow mononuclear cells from October 2004 to May 2005.Among them,3 patients were suffering from cerebral ischemia and 2 were in post operation of cerebral trauma.After aspiration of bone marrow blood from the ilium,the mononuclear cells were isolated and transplanted into patients by intravenous drip infusion.Results: No complications were found in this group.Five patients had improvements in neurological function.Among them,2 patients had mind instauration and could act to order.Muscle powers in 4 patients were improved to 1 or 3 grades.All of them corrected the aphasia to a degree.Conclusion: Autologous transplantation of bone-marrow mononuclear cells could be a simple,safe,and effective method to treat patients with neurological impairment.This therapy is worthy of further observation and practice.