The fundamental unit of synthetic melanin: a verification by tunneling microscopy of X-ray scattering results

Abstract A characteristic dimension of a melanin protomolecule synthesized from tyrosine has been investigated by scanning tunneling microscopy (STM). Identification of a melanin protomolecule of approximately ∼ 20 A lateral extent and ∼ 10 A height has been established. This size is in good agreement with models constructed to fit wide angle X-ray diffraction experiments on melanin. These protomolecules are believed to consist of Van der Waals interacting stacks of a basic random polymer of 5,6 indolequinone units. There is extensive π-delocalization within the individual polymeric sheets. Structure minimization and molecular orbital techniques were employed to verify the X-ray and STM results.