Correlation study on antiphospholipid antibody syndrome, prethrombotic state and the incidence of early onset severe preeclampsia

Objective To study the correlation of antiphospholipid antibody syndrome, prethrombotic state with the incidence of early onset severe preeclampsia, and to investigate the indexes for the early diagnosis of early onset severe preeclampsia. Methods Puerperants in our hospital with early onset severe preeclampsia (the early group, n=70) and late onset severe preeclampsia (the late group, n=70) were collected. At the same time, 70 normal pregnant women were randomly selected as the control group. The three groups were compared in glycerol three fat (TG), cholesterol (TC), coagulation index and serum anticardiolipin antibody, anti-β 2 -GPI antibody levels. Results For coagulation index, the antithrombin (AT) activity in the early group was significantly lower than that in the late group and the control group (P0.05). For TC, TG and D-dimer, the D-dimer average rank was 76.6 in the early group, significantly higher than 58.3 in the late-onset group and 54.1 in the control group (P0.05). The positive rates of ACA antibody and anti-β 2 -GPI antibody in the early group was significantly higher than those in the late group and the control group (P0.05). Conclusion Antithrombin, D-dimer, the positive rate of ACA antibody and anti-β 2 -GPI antibody can be used as the indexes for the early diagnosis of early onset severe preeclampsia.