The relationship between pelvic drop during walking and radiographic medial knee osteoarthritis: the most study

radiography in order to avoid radiation exposure. Five ml whole venous blood sample of the cases and controls were drawn. The serum level of COMP was estimated from the blood sample with the help of ELISA. The value of COMP thus obtained was compared with WOMAC score and KL grading scale. The cases were then divided into mild, moderate and severe grade. The cases were prescribed medications according to standard management guidelines of OARSI, depending upon severity and follow up was done after every four weeks to assess the efficacy of treatment and disease progression. No further follow up was done for control group. Results: Out of 25 male controls screened, the mean serum COMP level is found to be 490 ng/dl (minimum1⁄4 363 ng/dl &maximum1⁄4 596 ng/dl). Out of 25 female controls screened, the mean serum COMP level is found to be 464 ng/dl (minimum 1⁄4 313 ng/dl & maximum 1⁄4 614 ng/dl). Overall the mean COMP level among 50 controls found to be 477 ng/dl (minimum1⁄4 313 ng/dl & maximum 1⁄4 614 ng/dl). Out of 50 male cases screened, the mean serum COMP level is found to be 961 ng/dl (minimum 1⁄4 711 ng/dl & maximum 1⁄4 1408 ng/dl). Out of 50 female controls screened, the mean serum COMP level is found to be 968 ng/dl (minimum 1⁄4 691 ng/dl & maximum 1⁄4 1434 ng/dl). Overall the mean COMP level among 100 controls found to be 964 ng/dl (minimum1⁄4 691 ng/dl & maximum1⁄4 1434 ng/dl). In the study, the cases were divided into three groups, namely mild, moderate and severe, depending upon the clinical scoring and radiological grading. The result thus obtained shows 32% mild, 61% moderate and 7% severe cases. The serum COMP levels corresponds to the severity of disease, as higher the severity, more the value of serum COMP. Conclusion: The result indicates direct relation of serum COMP levels to the osteoarthritis process in human knee. Most of the patients having knee osteoarthritis have higher serum COMP levels. A directly proportional relation between the severity of disease and serum COMP levels have been observed. Thus estimation of serum COMP levels can be used as a reliable diagnostic indicator to assess severity assessment of knee osteoarthritis. Because of its strong association with knee osteoarthritis, further work in this area should be carried out, and serum COMP level should be used as an indicator to assess efficacy of ongoing treatment and to state prognosis of disease. Biomechanics & Gait 177 THE RELATIONSHIP BETWEEN PELVIC DROP DURING WALKING AND RADIOGRAPHIC MEDIAL KNEE OSTEOARTHRITIS: THE MOST STUDY