Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation

Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation☆ S.E. Cremer , N.E. Zois , S.G. Moesgaard , N. Ravn , S. Cirera , J.L. Honge , M.H. Smerup , J.M. Hasenkam , E. Sloth , P.S. Leifsson , T. Falk , M.A. Oyama , C. Orton , T. Martinussen , L.H. Olsen a,⁎,1 a Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark b Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark c Novo Nordisk A/S, Maaloev, Denmark d Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark e Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark f Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark g Department of Clinical Studies, University of Pennsylvania, Philadelphia, PA, USA h Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA i Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark