A method of preparing bent Ge Lieting

The present invention relates to a kind of methods for preparing bent Ge Lieting, the method comprising steps of (1) in reaction dissolvent, by 2- (the chloro- 3- methyl -2 of 6-, 4- diketone -3, 4- dihydro-pyrimidin-dihydro -1- methyl) -4-F- benzonitrile (I) number object addition R-3- amino piperidine dihydrochloride, ice bath is added dropwise 1, 11-7- alkene of 8- diaza-bicyclo [5.4.0], 15-25 DEG C, insulation reaction 2 hours, (2) reaction solution is adjusted to acidity with hydrochloric acid, (3) organic solvent is added and adjusts water phase pH to alkalinity, bent Ge Lieting crude product is obtained by extraction, (4) bent Ge Lieting is recrystallized to give with solvent.The bent Ge Lieting that this method obtains can effectively control chromatographic purity not less than 99.0%, and yield is not less than 75%, simple process and low cost.