Biochemical basics of imaging in positron emission tomography in oncology. Part 2

This article provides an overview of the main literature data of biochemical basics and the clinical application of positron emission tomography, one of the promising technologies of radiation imaging in oncology. In the current part we discuss in detail the biokinetics of radiopharmaceuticals used to visualize various groups of tumor cells receptors. These include angiogenesis markers - RGD peptides, ligands for somatostatin receptors, agents for sex hormone imaging, ligands for prostate-specific membrane antigen and to activating EGFR mutant kinase. It contains results of studies that were dedicated to search for optimal modifications of these radiopharmaceuticals to increase diagnostic efficiency, their comparative analysis is carried out, the results of their use in cancer research and development prospects in this industry are highlighted.