Gene expression of α‐endosulfine in the rat brain: correlative changes with aging, learning and stress
2003
Endosulfine (EDSF) belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family and was first isolated from ovine brain as a possible endogenous ligand for sulfonylurea receptors. To explore its involvement in brain functions, we investigated regional distribution of α-EDSF gene expression in the rat brain, and its regulation under physiological and pathological conditions. The majority of α-EDSF gene was expressed in the pyramidal neurons, which represent the principal excitatory neurons in various brain regions. Down-regulation of α-EDSF mRNA was detected in the rat hippocampus during long-term memory consolidation following a spatial learning experience, whereas swimming-related stress caused persistent up-regulation of α-EDSF gene expression in several brain regions. These changes, however, were absent from brains of diabetic rats that were subjected to the same behavioral treatments. Intracerebroventricular injection of streptozocin with a toxic dose induced severe learning deficits and brain structure alteration accompanied by a massive increase of α-EDSF mRNA in the somatosensory cortex. These results suggest that α-EDSF gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities.
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