Human miR-185* antisense nucleic acid and application thereof

The invention discloses antisense oligonucleotide inhibiting human microRNA-185* from expressing and application thereof. The antisense oligonucleotide is specifically combined with human miR-185*, contains a sequence complementary with at least 13 continuous nucleotides in a 5'-AGGGGCUGGCUUUCCUCUGGUC-3' nucleotide sequence, particularly a sequence of 5'-GACCAGAGGAAAGCCAGCCCCU-3'. The antisense oligonucleotide can be ribonucleotide, deoxyribonucleotide or chimera of both, and can modify any nucleotide in a chain. The miR-185* antisense oligonucleotide effectively inhibits miR-185* in a human glioma cell from expressing, and inhibits the cell from growing and propagating so as to effectively treat human glioma and other miR-185* high-expression tumors.