Increase in Serum Total Cholesterol and Low-Density Lipoprotein Cholesterol by High-Dose Chenodeoxycholic Acid in Patients with Radiolucent Gallstones Significantly Reversed during Preventive Low Dose after Gallstone Dissolution

This study examines the effects of high-dose chenodeoxycholic acid (CDCA) on serum lipids and lipoproteins in 25 patients who underwent a 12-month therapy with CDCA for the dissolution of cholesterol gallstones. All patients received a daily dose of CDCA of 15 mg/kg body weight. Complete dissolution of gallstones was achieved in 16 cases. After 6 months of therapy the mean total cholesterol levels and low-density lipoprotein cholesterol (C-LDL) significantly increased (p