CNS activity of leaves extract of Calotropis gigantea

Abstract Objective To study central nervous system activity of ethanolic extract of leaves of Calotropis gigantea ( C. gigantea ) (Asclepiadaceae), such as anticonvulsant, sedative and muscle relaxation activity. Methods The ethanolic extract of C. gigantea administered orally in experimental animals at different doses 100, 200 and 500 mg/kg body weight. The anticonvulsant properties were studied on maximal electroshock test and strychnine-induced convulsions model. Sedative property studied using actophotometer and skeletal muscle relaxant property studied using rota rod. Results This extract protected rats against maximal electroshock induced seizures, but had no or a moderate effect only against strychnine-induced seizures. Locomotor activity in mice found to be decreased and motor coordination was also decreased. The acute toxicity study revealed safely of the extract up to a dose of 2 000 mg/kg. Conclusions With these effects, the leaves of C. gigantea possess anticonvulsant sedative and muscle relaxant effect that might explain its use as a traditional medicine.