Facile, Efficient Synthesis of Polysubstituted Thiazoles via α‐Nitroepoxides and Thioureas.

Abstract An efficient synthesis of 2,4,5-trisubstituted thiazoles via the reaction of α-nitroepoxides and thioureas under mild conditions has been developed. This reaction proceeded well at room temperature, to afford products in excellent yields for a wide range of substrate, and a possible mechanism has also been proposed.