The Association study between angiotensinogen gene variation and hypertrophic cardiomyopathy

Objective To investigate the relationship between hypertrophic cardiomyopathy and angiotensinogen gene variation.Methods We genotyped the polymorphism of AGT gene in 225 HCM patients and 243 age-and sex-matched healthy controls.PCR-RFLP is used to genotype.Results The patients carrying A allele had a higher proportion of left ventricular outflow obstruction (30.1% versus 17.0%,P0.05) than those carrying GG genotype.After adjusted for age at diagnosis,sex,interventricular septum,family history of HCM and family history of sudden death by using multiple regression analysis,the A allele confers 2.4 fold risk for left ventricular outflow obstruction than GG genotype (adjusted OR=2.4,95%CI 1.2 to 4.8).Conclusion A allele of AGT might be a genetic contributor for patients with HCM to develop left ventricular outflow obstruction.