Иммунные нарушения и их коррекция озоном при детской форме тяжёлого атопического дерматита

The purpose of the research was to study the clinical and immunomodulatory effect of ozone therapy for children of preschool and junior-school age suffering from severe atopic dermatitis. 64 patients with atopic dermatitis (AD) at the age of 5-10 years (children form of disease) were under supervision. In all of them widespread heavy atopic dermatitis was diagnosed. The first group of AD patients (33 persons) was treated by complex conventional therapy. The second group of AD patients (31 persons) was prescribed complex therapy combined with two courses of ozone therapy. A course of ozone therapy consisted in applying ozonated olive oil to affected skin areas (twice a day within 15 days) and making rectal ozone-oxygen mixture insufflations (8 procedures in total, every other day). To assess the immunoreactivity state of AD patients in periods of acute condition and clinical remission, the parameters of cellular and humoral components of immune system, phagocytosis and the levels of inflammatory cytokines in blood serum were studied. In patients with infantile form of heavy atopic dermatitis treated by complex conventional therapy some marked immunoreactivity changes were revealed in the period of clinical remission. The inclusion of ozone therapy in the complex treatment of patients with infantile form of heavy atopic dermatitis will result in quicker incoming of clinical remission and normalization of the most parameters of immunoreactivity.