Proteinuria is a Predictor of Renal Functional Decline in Patients with Kidney Cancer

Purpose: Prior studies have shown that 26% to 34% of patients with suspected renal cancers have a glomerular filtration rate less than 60 ml/minute/1.73 m2 but limited information exists regarding proteinuria. We investigated the extent of proteinuria in patients with renal tumors to determine the impact on the classification and progression of chronic kidney disease.Materials and Methods: Among 1,622 patients evaluated between 1999 and 2014, 1,016 had preoperative creatinine and proteinuria measurements available. Patients were classified according to the risk of chronic kidney disease progression into low, moderately increased, high and very high risk groups according to 2012 KDIGO guidelines. Predictors of risk group and chronic kidney disease progression were analyzed using univariable and multivariate models.Results: Before treatment 32% had a glomerular filtration rate less than 60 ml/minute/1.73 m2. Preoperative proteinuria was present in 22%. Proteinuria was detected in 30% with a reduced glomerul...