Study on the High Sensitive C-reactive Protein Basic Values of Male Cynomolgus Monkeys and the Relationship with High-fat Diet Induced Blood Lipid Change

To investigate the high sensitive C-reactive protein( hs-CRP) baseline values of different ages of male cynomolgus monkeys,and the differences of the hs-CRP values induced by high-fat diet. Saphenous venous blood was collected and hs-CRP values were detected by the method of immunoturbidimetry. The middle-age cynomolgus monkeys were fed with high-fat diet,subsequently,the change of hs-CRP values and its relationship with total cholesterol were analyzed. The results showed that the mean value of old monkeys was obviously higher than that of middle-age and young monkeys( 6. 09 mg·L- 1± 2. 06 mg·L- 1VS. 2. 78 mg·L- 1± 1. 48 mg·L- 1 2. 31 mg·L- 1± 1. 52 mg·L- 1,P 0. 05).The mean hs-CRP value of old monkeys was also significantly higher than the mean value of the whole. Total cholesterol( TC) concentration and hs-CRP value of high-fat diet induced cynomolgus was significantly higher than that of the control group( P 0. 05). These results indicated that the high hs-CRP levels may be associated with TC levels of serum,and this could be considered as an early index in animal experiment of cardiovascular disease research. In this study,the basal hsCRP levels of male cynomolgus monkeys among different ages were determined,and there were differences among the different age groups. The hs-CRP levels were related with the blood lipids. This study could provide basic data for animal model research related to hyperlipidemia and cardiovascular disease,etc.