Derivatives of N-linked hydroxamic acid useful as antibacterial agents
2010
A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: R1 is represented by C1-C3 alkyl; R2 is represented by hydrogen or C1-C3 alkyl; R3 is represented by hydrogen, halogen, C1-C3, C1-C3 alkoxy, trifluoromethyl or trifluoromethoxy; L is absent, or is represented by a moiety selected from the group consisting of C1-C6 alkyl which may be optionally substituted in which up to 6 hydrogen atoms are substituted by a substituent selected from the group consisting of halogen , cyano, sulfonamide, imino, iminohidroxi, -OR, -SR and -NRaRb, wherein each of Ra and Rb is independently represented by hydrogen or C1-C6 alkyl; C2-C6; C2-C6 alkynylene; - (CH2) -O- (CH2) n, - (CH2) -O- (CH2) Zo (CH2) n-; n is represented by an integer between 0 and 4; p is represented by an integer between 0 and 4; q is represented by an integer between 0 and 6; z is represented by an integer from 1 to 4; D is represented by a substituent selected from the group consisting of: i) (C3-C10) saturated or partially unsaturated, wherein said cycloalkyl is an alkyl radical bicyclic, bicyclic or bridged tricyclic, wherein each cyclic moiety It is containing 3 to 10 carbon atoms, and wherein said cycloalkyl group may be optionally substituted, in which up to 4 hydrogen atoms are substituted by a substituent (s) selected from the group consisting of halogen , cyano, nitro, hydroxy, (C1-C6) alkyl, (C1-C6) alkyl, trifluoromethyl, trifluoromethoxy, phosphate, oxo, -SO2NR4R5, - (CH2) m-NR5-C (O) -R 4, - (CH2 ) mC (O) -N-R4R5, -C (O) R4, -C (O) -O-R4, -SR4, -SO2R4 and-NR4R5, substituents which may be the same or different; ii) aryl (C6-C10), optionally substituted with up to 4 non-hydrogen substituents, wherein each substituent is independently selected from the group consisting of halogen, cyano, nitro, hydroxy, (C1-C6), (C1-C6) alkyl, trifluoromethyl, trifluoromethoxy, phosphate, -SO2NR4R5, - (CH2) m-NR5-C (O) -R 4, - (CH2) mC (O) -N-R4R5, -C (O) R4 , -C (O) -O-R4, -SR4, -SO2R4 and-NR4R5, iii) heteroaryl, optionally substituted in which up to 4 carbon atoms of the heteroaryl moiety may be substituted with a substituent, each substituent is independently selected from the group consisting of halogen, cyano, nitro, hydroxy, (C1-C6) alkyl, (C1-C6) alkyl, trifluoromethyl, trifluoromethoxy, phosphate, SO2NR4R5, - (CH2) MNC (O) -R 4, - (CH2) mC (O) -N-R4R5, -C (O) -R 4, 35 -C (O) -O-R4, -SR4, -SO2R4 and-NR4R5, iv) heterocyclic, optionally substituted in which up up to 4 carbon atoms may be substituted heterocycle moiety co n one substituent, each substituent is independently selected from the group consisting of halogen, cyano, nitro, hydroxy, (C1-C6) alkyl, (C1-C6) alkyl, trifluoromethyl, trifluoromethoxy, phosphate, oxo, SO2NR4R5, - (CH2 ) MNC (O) -R 4, - (CH2) mC (O) -N-R4R5, -C (O) R4, -C (O) -O-R4, -SR4, -SO2R4 and -NR4R5, T is absent or is represented by -S- (CH2) Zo (CH2) n, -O- (CH2) ZS (CH2) n, - (CH2) q-, - (CH2) nC (O) - (CH2) p-, - (CH2) -O- (CH2) p-, - (CH2) n -S (CH2) p, S-alkylene-C1-C6, -O-alkylene-C1-C6, -O- (CH2) pC (O) - (CH2) n-. - (CH2) pC (O) - (CH2) qo- (CH2) n-, -O- (CH2) Zo (CH2) n-, -O- (CH2) Zo (CH2) Zo (CH2) n-, -S- (CH2) ZS (CH2) n-, - (CH2) n-SH or - (CH2) n-OH and.
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