Inhibition of glyoxalase I by thermal copolyamino acids

Variations in the composition of thermal copolyamino acids inhibitory for glyoxalase I have been studied. Those produced from both tryptophan and cysteine are the most active. The activity requires the polymeric state since the free amino acids are devoid of activity. On the basis of these studies and others elsewhere, hydrophobicily appears to be a significant physical property contributing to the activity of some of the inhibitors.