Mukaiyama Reagent as an Efficient Activating Agent for Anchoring Carboxylic Acids to Hydroxymethylated Resins

This work describes an efficient methodology based on the use of Mukaiyama reagent as an activating agent for the immobilization of diverse carboxylic acids to hydroxymethylated resins through an ester linkage. The reaction efficiency was high for aromatic and aliphatic acids, including synthetic and biologically promising penicillin derivatives.