Clinical observation of Concurrent chemoradiotherapy treatment of locally advanced nasopharyngeal carcinoma

Objective To investigate the synchronous radiotherapy and chemotherapy the efficacy of the treatment of advanced nasopharyngeal carcinoma patients after treatment tolerability.Methods 75 patients with locally advanced nasopharyngeal carcinoma patients were randomly divided into two groups,radiotherapy and chemotherapy group of 37 cases and 38 cases radiotherapy alone group.Radiotherapy and chemotherapy group were treated with radiotherapy Synchronous cisplatin chlorination uracil chemotherapy,and observe the clinical efficacy of the two groups of patients with adverse reactions.Result Radiotherapy and chemotherapy group,the total efficiency is 78.3%(29 cases),radiotherapy alone group,the total efficiency is 63.1%(24 cases),both statistically significant difference(P 0.05).Chemoradiotherapy group 3-year survival is 59.4%(22 cases),radiotherapy alone group 3-year survival was 39.4%(15 cases),the difference is also statistically significant(P0.05).Patients with adverse reactions to radiotherapy and chemotherapy group than the radiotherapy alone group,but after the patients in the symptomatic treatment could be tolerated.Conclusion Concurrent chemoradiotherapy can improve local control and survival rates of patients with advanced nasopharyngeal carcinoma,the patient can tolerate adverse reactions,is worthy of clinical application.