Prevalence of Drug-Induced Hepatitis and its Risk Factors in the Treatment of Tuberculosis in TB Infected Patients Attending Razi Hospital, 2006-2011

Background and purpose: Hepatotoxicity and elevated serum aminotransferase is a severe side effect of anti-Tuberculosis therapy and some cases could even develop hepatitis. This study aimed at determining the prevalence of drug induced hepatitis and predisposing factor after anti-Tuberculosis therapy in Razi hospital. Materials and methods: In this cross-sectional study we used the medical records of all confirmed cases of tuberculosis admitted at the infectious disease ward of Ghaemshahr Razi hospital between 2006-2011. Variables included age, sex, type of TB, other medications, basal levels of liver enzymes, enzyme changes during treatment, and co-infection (such as hepatitis B HIV). The diagnosis of drug induced hepatitis was done with at least five-fold increase of aminotransferase levels. Data was analyzed using SPSS17, chi square tests and Fisher's exact test. Results: Of 230 patients, 56.5% were male. The frequency of pulmonary TB and extra pulmonary TB was 91.7% and 8.3%, respectively. Standard treatment was used in 92.5% of patients with tuberculosis. 23.5% of patients had an underlying disease. Prevalence of drug-induced hepatitis in this study was 9.5%. There was no significant correlation between gender, type of tuberculosis and type of drug treatment with drug-induced hepatitis, but there was a significant relationship between age and drug-