COVID-19 Interference with Renin-Angiotensin System in the Context of Heart Failure.

Novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19] pandemic) attacks the host cells modulating the local renin-angiotensin (RAS) system. Pending a definitive antivirus therapy, Fedson and colleagues propose in their recent article (1) a combination of generic drugs such as statins and angiotensin receptor blockers (ARBs) to prevent catastrophic cellular damage. The proposal could be applicable in a model of heart failure (HF) patients infected by coronavirus. These patients belong to the most vulnerable groups while concentrating in …