Polyketides and Meroterpenoids from Neosartorya glabra

Two new polyketides, neosarphenols A and B (1 and 2, resp.), were isolated from Neosartorya glabra, together with six known polyketides, 3–8, and two meroterpenoids, 9 and 10. The structures of the new compounds were elucidated by comprehensive spectroscopic analysis, especially by HR-ESI-MS and NMR experiments. All compounds were evaluated for their cytotoxic activities against MDA-MB-231, MCF-7, and PANC-1 tumor cell lines; 1 and 6 exhibited selective and moderate cytotoxicities against PANC-1 cell line.