Systematic Review of Combination DMARD Therapy in Rheumatoid Arthritis

s: CCTR: 66 Medline: 71 Embase: 61 Total: 198 Met inclusion criteria Check other reviews: Duplicates 9 _ + Selected articles (inclusion criteria + other reviews – duplicates): 64 Accepted Rejected 28 35 (19 – no study 2 – language 5 – no RCT 9 – no combination therapy) Number of included studies: Total: 28 Our electronic search identified 2269 titles. Among these, 198 pertained to combination therapy with DMARDs for RA. The abstract for each selected title was reviewed and from these 64 articles were selected for review. Among these, 62 (97%) were retrieved and 24 met our inclusion criteria. The search of bibliographies of major articles and reviews resulted in eight more articles to be retrieved. Four of these eight met our inclusion criteria. Among the articles rejected, 17 did not describe a clinical trial,