Correlations of HACE1 expression with pathological stages, CT features and prognosis of hepatocellular carcinoma patients.

Purpose To explore the correlations of HECT domain and ankyrin repeat-containing E3 ubiquitin protein ligase 1 (HACE1) expression with the pathological stages, computed tomography (CT) features and prognosis of patients with hepatocellular carcinoma (HCC). Methods The clinical data were randomly collected from 70 patients with primary HCC. The messenger RNA (mRNA) and HACE1 in the cancer and paracancer tissues were determined via real-time quantitative-polymerase chain reaction (qRT-PCR). The curve of the relationship between HACE1 expression and patients' overall survival (OS) was plotted using the Kaplan-Meier method. Finally, the CT imaging data of patients were pooled to analyze the relationships of HACE1 expression with CT signs. Results Compared with those in the paracancer tissues, the mRNA and protein expression levels of HACE1 declined significantly in HCC tissues (p 0.05), but notably associated with the size, capsule and necrosis of tumors (p Conclusions HCC tissues are significantly deficient in HACE1, and the combination of HACE1 and CT images may serve as an efficacious strategy for the clinical diagnosis and monitoring of HCC.