Application of Copper (I) salt and Fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

The Stille coupling between organostannane and organohalide is an effective catalytic method for organic synthesis. Despite of the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of Cu(I) salt and fluoride. This review summarises the application this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.