ANTI-ULCEROGENIC ACTIVITIES OF TREWIA NUDIFLORA IN DIFFERENT EXPERIMENTAL MODELS

The purpose of the present study is to investigate the acute oral toxicity and anti-ulcerogenic activities of the ethanol Extract of Trewia nudiflora (EETN) leaf extract in albino rats. Study on acute toxicity of extract found to be safe at the doses 2000mg/kg body weight orally as per OECD guidelines No.423. EETN at the doses of 200 and 400 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using indomethacin and cold-restraint stress induced gastric ulcer models in Albino rats. Ethanol Extract of Trewia nudiflora dose dependent inhibition in indomethacin induced gastric lesions, and it also dose dependent inhibition in Cold-restraint stress induced gastric lesions. All the results are found to be statistically significant (p≤0.05). Hence we suggest that Ethanol Extract of the leaves of Trewia nudiflora possess anti-ulcerogenic properties that may be due to cytoprotective mechanism.