Study of the pyrimidine nucleobase C5C6 bond reactivity under thio-michael/aldol tandem reaction conditions
2006
Pyrimidine nucleobases can undergo a Michael/aldol tandem reaction triggered by a thiolate. In an intramolecular context, 5′-deoxy-2′,3′-isopropylidene-5′-thiouridine affords the reminiscent Baylis-Hillman adduct after retro-Michael addition whereas its thymine counterpart is unreactive. In an intermolecular context, the conjugate addition-aldol reaction occurs only if the C5C6 double bond is activated.
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