Outcome of Pregnancy and Follow‐up of Children Conceived by Ovulation Induction

Evaluation of gestational outcome was attempted in 271 pregnancies achieved with various methods of ovulation induction (gonadotropin, clomiphene, Sexovid and epimestrol). The overall abortion rate was 18.4%. Although the incidence of multiple pregnancy was high (20.0%) after human nemopausal gonadotropin therapy, it was not after clomiphene when used alone. The overall male/female ratio of the neonates and fetuses was 117.7/100, and the incidence of malformation found at birth was 1.8%. Body lengths and weights of the neonates at birth were similar to standard values in Japan, though body weights of those after gonadotropin therapy were slightly lighter. In an attempt to follow-up later developments of children born of mothers treated with ovulation-inducing agents, questionnaires were sent to 141 mothers and 113 replies were obtained. No particular tendency was observed in the malformations and/or abnormalities found at the time of follow-up or diseases suffered during the course of development. Body heights and weights of the children at the time of follow-up fitted well with the physical developmental curves for children throughout Japan.