3-(3-hydroxyphenyl)-N-(1-propyl)piperidine elicits convulsant effects in mice

Abstract 1. 1. The behaviour and EEG effects of the dopamine and sigma (σ) ligands (+) 3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)3-PPP) were studied in mice. 2. 2. (+) 3-PPP dose-dependently (60–100 mg/kg i.p.) produced behavioural and electrical tonic-clonic seizures. 3. 3. The incidence of the tonic seizures elicited by 100 mg/kg of the drug was significantly ( P 4. 4. The results show an influence on the behavioural and electrical threshold of convulsions by (+) 3-PPP depending on a prevalent interference on dopamine receptors.