Rat phenol-preferring sulfotransferase genes (Stp and Stp2) : localization to mouse chromosomes 7 and 17

Abstract The phenol-preferring sulfotransferases aryl sulfotransferase IV and N -hydroxyarylamine sulfotransferase catalyze sulfate conjugation of N -hydroxy-2-acetyl-aminofluorene, a metabolite capable of causing hepatocarcinogenesis in rats. We utilized published cDNA sequences of these sulfotransferases to type the progeny of two multilocus crosses and determined that the genes, aryl sulfotransferase ( Stp ) and N -hydroxyaryl-amine sulfotransferase ( Stp2 ), map to positions on mouse chromosomes 7 and 17.