BLADDER CAPACITY AND RENAL CONCENTRATING ABILITY IN ENURESIS: PATHOGENIC IMPLICATIONS

Purpose: We compared bladder volume and renal concentrating capacity in dry children and 2 distinct groups of children with enuresis to hypothesize about the pathogenesis of various types of enuresis.Materials and Methods: A total of 55 dry children and 100 with enuresis underwent an overnight thirst provocation test to assess renal concentrating capacity and completed a 2-day voiding chart to assess functional bladder capacity. The enuretic children were subdivided into 27 desmopressin responders and 73 desmopressin nonresponders before study inclusion.Results: The desmopressin responder group had lower average renal concentrating capacity ±1 standard deviation than dry children and desmopressin responders (856 ± 158 mOsm./kg. versus 939 ± 147 and 962 ± 151, respectively, p <0.05). Analogously average daytime urine production in the desmopressin responder group was greater than in dry children and desmopressin responders (22.2 ± 10.2 ml./kg. body weight versus 15.4 ± 7.3 and 15.3 ± 7.2, respectively, p <...