Anti-ischemic effects of celiprolol in patients with exercise-induced angina pectoris

Abstract The anti-ischemic properties of the new cardioselective β-adrenoreceptor antagonist celiprolol were investigated in an open study of 12 men (mean age: 58 ± 6.6 years) with exercise-induced angina pectoris. After all previous anti-anginal medication had been withdrawn for at least 5 half-lives, the patients received placebo, single doses of nitroglycerin buccal spray, sublingual nifedipine, celiprolol alone, and then in association with nitroglycerin and nifedipine. Exercise tests were performed on a bicycle ergometer, with continuous electrocardiographic monitoring. Significantly more work was completed after treatment with celiprolol than at baseline (5280 ± 2500 versus 4005 ± 1792 kpm; P P P