Is the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis

Céline Louapre,Sindhuja T. Govindarajan,Costanza Giannì,Julien Cohen-Adad,Gregory,Nielsen As,Nancy Madigan,Jacob A. Sloane,Revere P. Kinkel,Caterina Mainero

Is the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis

2016

Céline Louapre
Sindhuja T. Govindarajan
Costanza Giannì
Julien Cohen-Adad
Gregory
Nielsen As
Nancy Madigan
Jacob A. Sloane
Revere P. Kinkel
Caterina Mainero

Our results highlight a common tissue sensitivity to multiple sclerosis pathologic changes for intracortical and white matter demyelination that does not manifest exclusively through established anatomical connections.

Keywords:

Pathology
Tissue sensitivity
Multiple sclerosis
White matter
Magnetic resonance imaging
Cerebral cortex
Medicine
Anatomy
mr imaging

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