Nitric oxide synthase, Calcitonin Gene-Related Peptide and inflammatory mechanisms are involved in GTN induced neuronal activation.
2013
Infusion of glyceryl trinitrate (GTN), a nitric oxide (NO) donor in awake freely moving rats closely mimics a universally accepted human model of migraine and responds to sumatriptan treatment [1,2]. Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN induced neuronal activation in this model.
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