Stereoselective Construction of γ-Lactams via Copper-Catalyzed Borylacylation.

A versatile and highly stereoselective borylative cyclization to generate polyfunctionalized I³-lactams has been developed. The stereoselective synthesis of these key ring systems is crucial due to their ubiquity in natural products. We report the diastero- and enantioselective construction of di- and trisubstituted I³-lactam cores, with examples containing an enantioenriched quaternary carbon.